Posted in Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA Templates, DNA Testing, Elisa Kits, Enzymes, Exosomes, Gels, Isotypes, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits
A Systematic Review on the Association of Acquired Human Cytomegalovirus Infection with Hearing Loss
Default Cytomegalovirus infection (CMV) induces clinical syndrome which is usually associated with hearing loss. However, the effect of CVM infection obtained in adults and children has not been clearly defined. The purpose of this review is to critically assess the scientific evidence of the Association of CMV infection obtained by postnatal or tinnitus hearing loss. Systematic Overview of Records Reporting Sensorineural Loss (SNHL) or Tinnitus and CMV infection obtained including articles published in English is done.
The search strategy is limited to human studies with CMV infection obtained. After screening and quality assessment, nine studies involving 1528 individuals meet inclusion criteria. A total of 14% of patients with SNHL showed evidence of previous exposure to CMV, while in individuals without SNHL (control) percentage rose to 19.3%. SNHL was reported as unilateral or bilateral at 15.3%, and was not determined in 84.7% of cases. SNHL levels range from mild to deep for children and adults. None of the records reported by Tinitus.
The prevalence of children or adults with SNHL acquired by CMV infection obtained confirmed by polymerase chain reaction (PCR) or low IgM anti-CMV antibodies. Fenotyping of patients with CMV infection obtained is limited to hearing loss with pure tone audiometry and no additional audiological tests carried out in most studies. Additional symptoms deserve more attention, including vertigo episodic or tinnitus, because some patients with the clinical spectrum of meniere disease can result from a latent infection of CMV.
Nitrate oxide flows metabolic regulations mediated by a virus during human cytomegalovirus infection
Nitric Oxide is a multipurpose and critical effector molecule that can modulate many cellular functions. Although it is recognized as a regulator of infection, the inhibition mechanism of nitric oxide on human cytomegalovirus replication (HCMV) is still difficult to understand. We show that nitric oxide weakens viral replication by disrupting modulation mediated by HCMV from several cellular processes.
Nitric oxide exposure reduces the synthesis of HCMV genomes and offspring virus infections with differences depending on the type of cell. Mitochondrial respiration greatly reduced both in infected and infected cells HCMV during exposure with a slight impact at the ATP level which shows changes in cellular metabolism. Metabolomics identifies small molecules that change significantly in several routes during exposure to nitrate oxide including nucleotide biosynthesis, tricarboxylic acid cycles (TCA), and glutamine metabolism. Glutathione metabolites increased to coincide with the reduction of glutamine precursor glutathione.
This shift is accompanied by an increase in antioxidant enzymes. Glutamine deprivation imitated defects in HCMV replication and mitochondrial respiration observed during exposure to nitrate oxide. This data shows that nitric oxide limits glutamineolysis by diverting glutamine to glutathione synthesis. In addition, lipid intermediaries are challenuous, which is likely to contribute to the increase in virus particles observed. Nitric Oxide interferes with several cellular processes, and we have limited success in saving defects replication by adding metabolic intermediaries. Our studies show that the ace of nitrate oxide from HCMV is multifactorial with interference with cellular metabolic viruses that play a central role. The importance of human cytomegalovirus is a common pathogen in patients with a compromised immune system, including transplant patients and during innate infections. Lytic HCMV replication is likely to occur on local infection sites with immune cells that infiltrate and release nitrate oxide with other effector molecules.

The clinical results of the recipients of alogenic hematopoietic stem cell transplants develop DNAEMIA CYTOMEGALOVIRUS before the endraftment
There is limited information about the impact of DNAEMIA CMV episodes that develop before the endraftment (pre-cmv dnaemia) in clinical results after alogenic hematopoietic stem cell transplantation (allo-HSCT). This problem is intended for retrospective multicenter studies currently including 878 patients. All participating centers use the preemptive antivirus therapy strategy for prevention of CMV disease. The load of CMV DNA in the blood is monitored by a real-time PCR test. A total of 144 patients (cumulative events were 16.5%, 95% CI, 14% -19%) had a pre-CMV dnaemia episode on the median 10 days after allo-HSCT.
Patients who develop pre-CMV Dnaemia have a significant probability of recurrent episodes (P = <0.001) (50%) than those who experience post-CMV dnaemia (32.9%); However, the incidence of comparable CMV disease (p = 0.52). The cumulative incidence of the overall death (OM) and non-relapse mortality (NRM) at 1 year after the Allo-HSCT was 32% (95% CI, 29-35%) and 23% (95% CI 20-26%), respectively -Masing. The risk of OM and NRM in a customized model emerged proportion to patients who developed a DNAemia CMV episode, regardless of whether it happened before or after the endraftment, in patients with CMV CMV episodes before and post-engraftment or on those without CMV Dnaemia.
Cytomegalovirus Retinitis After transplantation of alogenic hematopoietic stem cells under the active screening of cytomegalovirus antigenemia
Although Cytomegalovirus (CMV) remains a major cause of morbidity and mortality after transplantation of hematopoietic stem cells (HSCT), the incidence of CMV retinitis is considered lower than the incidence of CMV infection in other organs after the shite. In this study, the incidence and characteristics of CMV retinitis were retrospectively evaluated at the Alogenic HSCT receiver. Eye playback is carried out on the development of ocular symptoms or positive CMV infections using peripheral blood evaluated by antigenemia PP65 or a polymerase chain reaction. Of the 514 patients, 13 patients developed CMV retinitis. The median onset of CMV retinitis is day 34 (range, 21-118) post transplants, and cumulative events are 2.5% (95% CI, 1.6-42) at 6 months after transplantation.
NUMBL Antibody |
E92140 |
EnoGene |
100ul |
EUR 255 |
Description: Available in various conjugation types. |
anti- NUMBL antibody |
FNab05917 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against NUMBL |
anti- NUMBL antibody |
FNab05918 |
FN Test |
100µg |
EUR 702 |
|
Description: Antibody raised against NUMBL |
NUMBL Antibody, HRP conjugated |
1-CSB-PA897595LB01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
NUMBL Antibody, FITC conjugated |
1-CSB-PA897595LC01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
NUMBL Antibody, Biotin conjugated |
1-CSB-PA897595LD01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
NUMBL Conjugated Antibody |
C38379 |
SAB |
100ul |
EUR 476.4 |
NUMBL Polyclonal Antibody |
E914088 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Polyclonal NUMBL Antibody (N-Term) |
AMM06872G |
Leading Biology |
0.1 mg |
EUR 580.8 |
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human NUMBL (N-Term). This antibody is tested and proven to work in the following applications: |
Polyclonal NUMBLIKE / NUMBL Antibody (N-Terminus) |
AMM06873G |
Leading Biology |
0.05ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NUMBLIKE / NUMBL (N-Terminus). This antibody is tested and proven to work in the following applications: |
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody |
abx235917-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody |
abx235918-100ug |
Abbexa |
100 ug |
EUR 661.2 |
|
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody |
abx117223-100ug |
Abbexa |
100 ug |
EUR 560.4 |
|
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody |
20-abx334204 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody |
abx431475-200ul |
Abbexa |
200 ul |
EUR 460.8 |
|
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody |
20-abx001752 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (HRP) |
20-abx336868 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (FITC) |
20-abx336869 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
NUMBL Polyclonal Antibody, HRP Conjugated |
A70356 |
EpiGentek |
-
EUR 754.26
-
EUR 293.70
-
EUR 470.80
|
|
NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (Biotin) |
20-abx336870 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
NUMBL Polyclonal Antibody, FITC Conjugated |
A70357 |
EpiGentek |
-
EUR 754.26
-
EUR 293.70
-
EUR 470.80
|
|
NUMBL Polyclonal Antibody, Biotin Conjugated |
A70358 |
EpiGentek |
-
EUR 754.26
-
EUR 293.70
-
EUR 470.80
|
|
NUMBL siRNA |
20-abx903703 |
Abbexa |
|
|
|
NUMBL siRNA |
20-abx926610 |
Abbexa |
|
|
|
NUMBL siRNA |
20-abx926611 |
Abbexa |
|
|
|
NUMBL Peptide |
43-109P |
ProSci |
0.1 mg |
EUR 405.6 |
NUMBL Rabbit pAb |
A14088-100ul |
Abclonal |
100 ul |
EUR 369.6 |
NUMBL Rabbit pAb |
A14088-200ul |
Abclonal |
200 ul |
EUR 550.8 |
NUMBL Rabbit pAb |
A14088-20ul |
Abclonal |
20 ul |
EUR 219.6 |
NUMBL Rabbit pAb |
A14088-50ul |
Abclonal |
50 ul |
EUR 267.6 |
NUMBL Rabbit pAb |
A2140-100ul |
Abclonal |
100 ul |
EUR 369.6 |
NUMBL Rabbit pAb |
A2140-200ul |
Abclonal |
200 ul |
EUR 550.8 |
NUMBL Rabbit pAb |
A2140-20ul |
Abclonal |
20 ul |
EUR 219.6 |
NUMBL Rabbit pAb |
A2140-50ul |
Abclonal |
50 ul |
EUR 267.6 |
NUMBL rabbit pAb |
E28PN4724 |
EnoGene |
100μl |
EUR 255 |
Description: Available in various conjugation types. |
NUMBL Rabbit pAb |
E2514088 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
NUMBL cloning plasmid |
CSB-CL897595HU-10ug |
Cusabio |
10ug |
EUR 704.4 |
|
Description: A cloning plasmid for the NUMBL gene. |
NUMBL Blocking Peptide |
DF6863-BP |
Affbiotech |
1mg |
EUR 234 |
Rat NUMBL shRNA Plasmid |
20-abx988573 |
Abbexa |
|
|
|
Human NUMBL shRNA Plasmid |
20-abx956126 |
Abbexa |
|
|
|
Mouse NUMBL shRNA Plasmid |
20-abx971842 |
Abbexa |
|
|
|
NUMBL Recombinant Protein (Rat) |
RP214829 |
ABM |
100 ug |
Ask for price |
Numbl ORF Vector (Rat) (pORF) |
ORF071611 |
ABM |
1.0 ug DNA |
EUR 607.2 |
NUMBL Recombinant Protein (Human) |
RP021901 |
ABM |
100 ug |
Ask for price |
NUMBL Recombinant Protein (Mouse) |
RP155453 |
ABM |
100 ug |
Ask for price |
NUMBL ORF Vector (Human) (pORF) |
ORF007301 |
ABM |
1.0 ug DNA |
EUR 114 |
Numbl ORF Vector (Mouse) (pORF) |
ORF051819 |
ABM |
1.0 ug DNA |
EUR 607.2 |
Human NUMBL Protein Lysate 20ug |
IHUNUMBLPLLY20UG |
Innovative research |
each |
EUR 361 |
|
Description: Human NUMBL Protein Lysate 20ug |
Human Numb- like protein, NUMBL ELISA KIT |
ELI-44511h |
Lifescience Market |
96 Tests |
EUR 988.8 |
Numbl 3'UTR GFP Stable Cell Line |
TU264290 |
ABM |
1.0 ml |
Ask for price |
Numbl 3'UTR GFP Stable Cell Line |
TU164428 |
ABM |
1.0 ml |
Ask for price |
NUMBL 3'UTR GFP Stable Cell Line |
TU066094 |
ABM |
1.0 ml |
EUR 1825.2 |
Numbl sgRNA CRISPR Lentivector set (Rat) |
K7619801 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
Numbl sgRNA CRISPR Lentivector set (Mouse) |
K4473701 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
NUMBL sgRNA CRISPR Lentivector set (Human) |
K1467301 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
NUMBL Protein Vector (Rat) (pPM-C-HA) |
PV286444 |
ABM |
500 ng |
EUR 723.6 |
NUMBL Protein Vector (Rat) (pPB-C-His) |
PV286442 |
ABM |
500 ng |
EUR 723.6 |
NUMBL Protein Vector (Rat) (pPB-N-His) |
PV286443 |
ABM |
500 ng |
EUR 723.6 |
NUMBL Protein Vector (Rat) (pPM-C-His) |
PV286445 |
ABM |
500 ng |
EUR 723.6 |
NUMBL Protein Vector (Human) (pPM-C-HA) |
PV029203 |
ABM |
500 ng |
Ask for price |
NUMBL Protein Vector (Mouse) (pPM-C-HA) |
PV207276 |
ABM |
500 ng |
EUR 723.6 |
NUMBL Protein Vector (Human) (pPB-C-His) |
PV029201 |
ABM |
500 ng |
Ask for price |
NUMBL Protein Vector (Human) (pPB-N-His) |
PV029202 |
ABM |
500 ng |
Ask for price |
NUMBL Protein Vector (Human) (pPM-C-His) |
PV029204 |
ABM |
500 ng |
Ask for price |
NUMBL Protein Vector (Mouse) (pPB-C-His) |
PV207274 |
ABM |
500 ng |
EUR 723.6 |
NUMBL Protein Vector (Mouse) (pPB-N-His) |
PV207275 |
ABM |
500 ng |
EUR 723.6 |
NUMBL Protein Vector (Mouse) (pPM-C-His) |
PV207277 |
ABM |
500 ng |
EUR 723.6 |
Numbl 3'UTR Luciferase Stable Cell Line |
TU214290 |
ABM |
1.0 ml |
Ask for price |
Numbl 3'UTR Luciferase Stable Cell Line |
TU114428 |
ABM |
1.0 ml |
Ask for price |
NUMBL 3'UTR Luciferase Stable Cell Line |
TU016094 |
ABM |
1.0 ml |
EUR 1825.2 |
Numbl sgRNA CRISPR Lentivector (Rat) (Target 1) |
K7619802 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Numbl sgRNA CRISPR Lentivector (Rat) (Target 2) |
K7619803 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Numbl sgRNA CRISPR Lentivector (Rat) (Target 3) |
K7619804 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Numbl sgRNA CRISPR Lentivector (Mouse) (Target 1) |
K4473702 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Numbl sgRNA CRISPR Lentivector (Mouse) (Target 2) |
K4473703 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Numbl sgRNA CRISPR Lentivector (Mouse) (Target 3) |
K4473704 |
ABM |
1.0 ug DNA |
EUR 184.8 |
NUMBL sgRNA CRISPR Lentivector (Human) (Target 1) |
K1467302 |
ABM |
1.0 ug DNA |
EUR 184.8 |
NUMBL sgRNA CRISPR Lentivector (Human) (Target 2) |
K1467303 |
ABM |
1.0 ug DNA |
EUR 184.8 |
NUMBL sgRNA CRISPR Lentivector (Human) (Target 3) |
K1467304 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Human NUMB Like, Endocytic Adaptor Protein (NUMBL) ELISA Kit |
abx381926-96tests |
Abbexa |
96 tests |
EUR 1093.2 |
|
NUMBL Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV) |
LV661351 |
ABM |
1.0 ug DNA |
EUR 818.4 |
NUMBL Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC) |
LV661355 |
ABM |
1.0 ug DNA |
EUR 818.4 |
NUMBL Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a) |
LV661356 |
ABM |
1.0 ug DNA |
EUR 818.4 |
Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat) |
K7619805 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse) |
K4473705 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
NUMBL sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
K1467305 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1) |
K7619806 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2) |
K7619807 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3) |
K7619808 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1) |
K4473706 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2) |
K4473707 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3) |
K4473708 |
ABM |
1.0 ug DNA |
EUR 200.4 |
NUMBL sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
K1467306 |
ABM |
1.0 ug DNA |
EUR 200.4 |
NUMBL sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
K1467307 |
ABM |
1.0 ug DNA |
EUR 200.4 |
NUMBL sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
K1467308 |
ABM |
1.0 ug DNA |
EUR 200.4 |
NUMBL Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA) |
LV661352 |
ABM |
1.0 ug DNA |
EUR 818.4 |
NUMBL Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro) |
LV661353 |
ABM |
1.0 ug DNA |
EUR 888 |
NUMBL Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro) |
LV661354 |
ABM |
1.0 ug DNA |
EUR 888 |
Rabbit Anti Human NUMBL Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot) |
IRBAMLNUMBLAP15120UL |
Innovative research |
each |
EUR 320 |
|
Description: Rabbit Anti Human NUMBL Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot) |
Rabbit Anti Human NUMBL Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot) |
IRBAMLNUMBLAP15200UL |
Innovative research |
each |
EUR 530 |
|
Description: Rabbit Anti Human NUMBL Polyclonal Affinity Purified (PBS with 0.02% sodium azide, 50% glycerol, pH7.3) (Western Blot) |
Rabbit anti-NUMBL Antibody |
YLD5676-100ul |
Shanghai YL Biotech |
100 ul |
EUR 320 |
|
Description: Rabbit polyclonal antibody to NUMBL |
Rabbit anti-NUMBL Antibody |
YLD5676-50ul |
Shanghai YL Biotech |
50 ul |
EUR 200 |
|
Description: Rabbit polyclonal antibody to NUMBL |
Rabbit anti-NUMBL Antibody |
DL97662A-100ul |
DL Develop |
100 ul |
EUR 270 |
|
Description: Numb-like protein; Numb-related protein; Numb-R |
Rabbit anti-NUMBL Antibody |
DL97662A-50ul |
DL Develop |
50 ul |
EUR 189 |
|
Description: Numb-like protein; Numb-related protein; Numb-R |
Numb Homolog (NUMB) Antibody |
20-abx101020 |
Abbexa |
-
EUR 510.00
-
EUR 159.60
-
EUR 1446.00
-
EUR 693.60
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
Numb Homolog (NUMB) Antibody |
20-abx101021 |
Abbexa |
-
EUR 526.80
-
EUR 159.60
-
EUR 1479.60
-
EUR 710.40
-
EUR 393.60
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
|
|
NUMB antibody |
10R-5100 |
Fitzgerald |
100 ul |
EUR 829.2 |
Description: Mouse monoclonal NUMB antibody |
NUMB antibody |
10R-5101 |
Fitzgerald |
100 ul |
EUR 829.2 |
Description: Mouse monoclonal NUMB antibody |
NUMB antibody |
10R-5102 |
Fitzgerald |
100 ul |
EUR 829.2 |
Description: Mouse monoclonal NUMB antibody |
NUMB Antibody |
25307-100ul |
SAB |
100ul |
EUR 468 |
NUMB Antibody |
6311-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: NUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53. |
NUMB Antibody |
6311-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: NUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53. |
NUMB Antibody |
49415-100ul |
SAB |
100ul |
EUR 399.6 |
NUMB Antibody |
49415-50ul |
SAB |
50ul |
EUR 286.8 |
NUMB antibody |
70R-18998 |
Fitzgerald |
50 ul |
EUR 522 |
Description: Rabbit polyclonal NUMB antibody |
NUMB Antibody |
35497-100ul |
SAB |
100ul |
EUR 468 |
NUMB Antibody |
36663-100ul |
SAB |
100ul |
EUR 302.4 |
NUMB Antibody |
1-CSB-PA005466 |
Cusabio |
|
|
|
Description: A polyclonal antibody against NUMB. Recognizes NUMB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
NUMB Antibody |
1-CSB-PA909836 |
Cusabio |
|
|
|
Description: A polyclonal antibody against NUMB. Recognizes NUMB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:2000, WB:1:200-1:1000 |
NUMB Antibody |
1-CSB-PA016186DSR2HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against NUMB. Recognizes NUMB from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000 |
NUMB Antibody |
1-CSB-PA016186GA01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against NUMB. Recognizes NUMB from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
NUMB Antibody |
F41458-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
Description: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. |
NUMB Antibody |
F41458-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
Description: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. |
NUMB Antibody |
R35011-100UG |
NSJ Bioreagents |
100 ug |
EUR 339.15 |
Description: Additional name(s) for this target protein: Protein S171 |
Five patients present ocular symptoms on onset. In eight asymptomatic patients remaining, the diagnosis of CMV retinitis is made by screening guided by a positive CMV infection. All patients can be evaluated responding to antivirus treatment but three shows an increase incomplete with the sequel to ocular. Our results show that the incidence of CMV retinitis after the Alogenic HSCT cannot be ignored and active ophthalmological screening is not only based on symptoms but also monitoring positive CMV infection contributes to early diagnosis of CMV retinitis.