A Systematic Review on the Association of Acquired Human Cytomegalovirus Infection with Hearing Loss

A Systematic Review on the Association of Acquired Human Cytomegalovirus Infection with Hearing Loss

Default Cytomegalovirus infection (CMV) induces clinical syndrome which is usually associated with hearing loss. However, the effect of CVM infection obtained in adults and children has not been clearly defined. The purpose of this review is to critically assess the scientific evidence of the Association of CMV infection obtained by postnatal or tinnitus hearing loss. Systematic Overview of Records Reporting Sensorineural Loss (SNHL) or Tinnitus and CMV infection obtained including articles published in English is done.

The search strategy is limited to human studies with CMV infection obtained. After screening and quality assessment, nine studies involving 1528 individuals meet inclusion criteria. A total of 14% of patients with SNHL showed evidence of previous exposure to CMV, while in individuals without SNHL (control) percentage rose to 19.3%. SNHL was reported as unilateral or bilateral at 15.3%, and was not determined in 84.7% of cases. SNHL levels range from mild to deep for children and adults. None of the records reported by Tinitus.

The prevalence of children or adults with SNHL acquired by CMV infection obtained confirmed by polymerase chain reaction (PCR) or low IgM anti-CMV antibodies. Fenotyping of patients with CMV infection obtained is limited to hearing loss with pure tone audiometry and no additional audiological tests carried out in most studies. Additional symptoms deserve more attention, including vertigo episodic or tinnitus, because some patients with the clinical spectrum of meniere disease can result from a latent infection of CMV.

Nitrate oxide flows metabolic regulations mediated by a virus during human cytomegalovirus infection

Nitric Oxide is a multipurpose and critical effector molecule that can modulate many cellular functions. Although it is recognized as a regulator of infection, the inhibition mechanism of nitric oxide on human cytomegalovirus replication (HCMV) is still difficult to understand. We show that nitric oxide weakens viral replication by disrupting modulation mediated by HCMV from several cellular processes.

Nitric oxide exposure reduces the synthesis of HCMV genomes and offspring virus infections with differences depending on the type of cell. Mitochondrial respiration greatly reduced both in infected and infected cells HCMV during exposure with a slight impact at the ATP level which shows changes in cellular metabolism. Metabolomics identifies small molecules that change significantly in several routes during exposure to nitrate oxide including nucleotide biosynthesis, tricarboxylic acid cycles (TCA), and glutamine metabolism. Glutathione metabolites increased to coincide with the reduction of glutamine precursor glutathione.

This shift is accompanied by an increase in antioxidant enzymes. Glutamine deprivation imitated defects in HCMV replication and mitochondrial respiration observed during exposure to nitrate oxide. This data shows that nitric oxide limits glutamineolysis by diverting glutamine to glutathione synthesis. In addition, lipid intermediaries are challenuous, which is likely to contribute to the increase in virus particles observed. Nitric Oxide interferes with several cellular processes, and we have limited success in saving defects replication by adding metabolic intermediaries. Our studies show that the ace of nitrate oxide from HCMV is multifactorial with interference with cellular metabolic viruses that play a central role. The importance of human cytomegalovirus is a common pathogen in patients with a compromised immune system, including transplant patients and during innate infections. Lytic HCMV replication is likely to occur on local infection sites with immune cells that infiltrate and release nitrate oxide with other effector molecules.

A Systematic Review on the Association of Acquired Human Cytomegalovirus Infection with Hearing Loss

The clinical results of the recipients of alogenic hematopoietic stem cell transplants develop DNAEMIA CYTOMEGALOVIRUS before the endraftment

There is limited information about the impact of DNAEMIA CMV episodes that develop before the endraftment (pre-cmv dnaemia) in clinical results after alogenic hematopoietic stem cell transplantation (allo-HSCT). This problem is intended for retrospective multicenter studies currently including 878 patients. All participating centers use the preemptive antivirus therapy strategy for prevention of CMV disease. The load of CMV DNA in the blood is monitored by a real-time PCR test. A total of 144 patients (cumulative events were 16.5%, 95% CI, 14% -19%) had a pre-CMV dnaemia episode on the median 10 days after allo-HSCT.

Patients who develop pre-CMV Dnaemia have a significant probability of recurrent episodes (P = <0.001) (50%) than those who experience post-CMV dnaemia (32.9%); However, the incidence of comparable CMV disease (p = 0.52). The cumulative incidence of the overall death (OM) and non-relapse mortality (NRM) at 1 year after the Allo-HSCT was 32% (95% CI, 29-35%) and 23% (95% CI 20-26%), respectively -Masing. The risk of OM and NRM in a customized model emerged proportion to patients who developed a DNAemia CMV episode, regardless of whether it happened before or after the endraftment, in patients with CMV CMV episodes before and post-engraftment or on those without CMV Dnaemia.

Cytomegalovirus Retinitis After transplantation of alogenic hematopoietic stem cells under the active screening of cytomegalovirus antigenemia

Although Cytomegalovirus (CMV) remains a major cause of morbidity and mortality after transplantation of hematopoietic stem cells (HSCT), the incidence of CMV retinitis is considered lower than the incidence of CMV infection in other organs after the shite. In this study, the incidence and characteristics of CMV retinitis were retrospectively evaluated at the Alogenic HSCT receiver. Eye playback is carried out on the development of ocular symptoms or positive CMV infections using peripheral blood evaluated by antigenemia PP65 or a polymerase chain reaction. Of the 514 patients, 13 patients developed CMV retinitis. The median onset of CMV retinitis is day 34 (range, 21-118) post transplants, and cumulative events are 2.5% (95% CI, 1.6-42) at 6 months after transplantation.

NUMBL Antibody

DF6863-200ul 200ul
EUR 350

NUMBL Antibody

ABD6863 100 ug
EUR 525.6

NUMBL Antibody

1-CSB-PA897595LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

NUMBL Antibody

R36056-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Numb-like

anti- NUMBL antibody

FNab05917 100µg
EUR 606.3
Description: Antibody raised against NUMBL

anti- NUMBL antibody

FNab05918 100µg
EUR 702
Description: Antibody raised against NUMBL

NUMBL Antibody, HRP conjugated

1-CSB-PA897595LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

NUMBL Antibody, FITC conjugated

1-CSB-PA897595LC01HU
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  • 100ug
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Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

NUMBL Antibody, Biotin conjugated

1-CSB-PA897595LD01HU
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  • 100ug
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Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OAAJ07337-100UL - NUMBL Antibody

OAAJ07337-100UL 100uL
EUR 319

NUMBL Polyclonal Antibody

E914088 100ul
EUR 225
Description: Available in various conjugation types.

NUMBL Conjugated Antibody

C38379 100ul
EUR 476.4

NUMBL Polyclonal Antibody

A70355
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  • 100 ?g
  • 20 ul
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  • 100 ul

Polyclonal NUMBL Antibody (N-Term)

AMM06872G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human NUMBL (N-Term). This antibody is tested and proven to work in the following applications:

Polyclonal NUMBLIKE / NUMBL Antibody (N-Terminus)

AMM06873G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NUMBLIKE / NUMBL (N-Terminus). This antibody is tested and proven to work in the following applications:

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx431475-200ul 200 ul
EUR 460.8

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

20-abx334204
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  • 100 ug
  • 1 mg
  • 200 ug
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NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx235917-100ug 100 ug
EUR 577.2

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx235918-100ug 100 ug
EUR 661.2

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx117223-100ug 100 ug
EUR 560.4

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

20-abx001752
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  • 100 ul
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NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx001752-100l 100 µl
EUR 387.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx001752-20l 20 µl
EUR 175

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx001752-50l 50 µl
EUR 275

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx235917-100g 100 µg
EUR 350

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx235918-100g 100 µg
EUR 350

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx117223-100g 100 µg
EUR 450

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx431475-200l 200 µl
EUR 387.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx433691-100g 100 µg
EUR 387.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx334204-100g 100 µg
EUR 362.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx334204-20g 20 µg
EUR 162.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody

abx334204-50g 50 µg
EUR 250

Numbl/ Rat Numbl ELISA Kit

ELI-44882r 96 Tests
EUR 1063.2

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (HRP)

20-abx336868
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  • 100 ug
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NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (HRP)

abx336868-100g 100 µg
EUR 362.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (HRP)

abx336868-20g 20 µg
EUR 162.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (HRP)

abx336868-50g 50 µg
EUR 250

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (FITC)

20-abx336869
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  • 100 ug
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NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (FITC)

abx336869-100g 100 µg
EUR 362.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (FITC)

abx336869-20g 20 µg
EUR 162.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (FITC)

abx336869-50g 50 µg
EUR 250

NUMBL

CSB-CL897595HU 10 μg plasmid + 200μl Glycerol Ask for price

NUMBL Polyclonal Antibody, HRP Conjugated

A70356
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  • 100 ?g
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NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (Biotin)

20-abx336870
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  • 100 ug
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NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (Biotin)

abx336870-100g 100 µg
EUR 362.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (Biotin)

abx336870-20g 20 µg
EUR 162.5

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (Biotin)

abx336870-50g 50 µg
EUR 250

NUMBL Polyclonal Antibody, FITC Conjugated

A70357
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  • 100 ?g
  • 50 ul
  • 100 ul

Numbl (GFP-tagged) - Mouse numb-like (Numbl)

MG209340 10 µg Ask for price

Numbl (untagged) - Mouse numb-like (Numbl), (10ug)

MC202603 10 µg Ask for price

NUMBL Polyclonal Antibody, Biotin Conjugated

A70358
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  • 100 ?g
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  • 100 ul

Numbl (Myc-DDK-tagged) - Mouse numb-like (Numbl)

MR209340 10 µg Ask for price

NUMBL mouse monoclonal antibody,clone OTI4A1

TA812189 100 µl Ask for price

NUMBL mouse monoclonal antibody,clone OTI4A1

TA812189S 30 µl Ask for price

NUMBL mouse monoclonal antibody,clone OTI6H7

TA812190 100 µl Ask for price

NUMBL mouse monoclonal antibody,clone OTI6H7

TA812190S 30 µl Ask for price

NUMBL mouse monoclonal antibody,clone OTI8D2

TA812202 100 µl Ask for price

NUMBL mouse monoclonal antibody,clone OTI8D2

TA812202S 30 µl Ask for price

NUMBL siRNA

20-abx926610
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  • 15 nmol
  • 30 nmol

NUMBL siRNA

20-abx926611
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  • 15 nmol
  • 30 nmol

NUMBL siRNA

20-abx903703
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  • 15 nmol
  • 30 nmol

NUMBL Peptide

43-109P 0.1 mg
EUR 405.6

NUMBL (untagged)-Human numb homolog (Drosophila)-like (NUMBL)

SC314186 10 µg Ask for price

NUMBL (GFP-tagged) - Human numb homolog (Drosophila)-like (NUMBL)

RG216869 10 µg Ask for price

NUMBL (N-term) goat polyclonal antibody, Aff - Purified

AP32925PU-N 100 µg Ask for price

Lenti ORF clone of Numbl (mGFP-tagged) - Mouse numb-like (Numbl)

MR209340L4 10 µg Ask for price

NUMBL Rabbit pAb

E2514088 100ul
EUR 225
Description: Available in various conjugation types.

NUMBL rabbit pAb

E28PN4724 100μl
EUR 255
Description: Available in various conjugation types.

NUMBL Rabbit pAb

A14088-100ul 100 ul
EUR 369.6

NUMBL Rabbit pAb

A14088-200ul 200 ul
EUR 550.8

NUMBL Rabbit pAb

A14088-20ul 20 ul
EUR 219.6

NUMBL Rabbit pAb

A14088-50ul 50 ul
EUR 267.6

NUMBL Rabbit pAb

A2140-100ul 100 ul
EUR 369.6

NUMBL Rabbit pAb

A2140-200ul 200 ul
EUR 550.8

NUMBL Rabbit pAb

A2140-20ul 20 ul
EUR 219.6

NUMBL Rabbit pAb

A2140-50ul 50 ul
EUR 267.6

NUMBL rabbit pAb

E44H13608 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Lenti ORF clone of Numbl (Myc-DDK-tagged) - Mouse numb-like (Numbl)

MR209340L3 10 µg Ask for price

NUMBL (Myc-DDK-tagged)-Human numb homolog (Drosophila)-like (NUMBL)

RC216869 10 µg Ask for price

Numbl (untagged ORF) - Rat numb homolog (Drosophila)-like (Numbl), (10 ug)

RN204216 10 µg Ask for price

NUMBL cloning plasmid

CSB-CL897595HU-10ug 10ug
EUR 704.4
Description: A cloning plasmid for the NUMBL gene.

NUMBL Blocking Peptide

DF6863-BP 1mg
EUR 234

Lenti ORF particles, Numbl (GFP-tagged) - Mouse numb-like (Numbl), 200ul, >10^7 TU/mL

MR209340L4V 200 µl Ask for price

NUMBL (untagged) - Human numb homolog (Drosophila)-like (NUMBL), transcript variant 2

SC336820 10 µg Ask for price

NUMBL (untagged) - Human numb homolog (Drosophila)-like (NUMBL), transcript variant 3

SC336821 10 µg Ask for price

NUMBL ELISA KIT|Human

EF001382 96 Tests
EUR 826.8

Rat NUMBL shRNA Plasmid

20-abx988573
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  • 150 µg
  • 300 µg

Lenti ORF particles, Numbl (Myc-DDK-tagged) - Mouse numb-like (Numbl), 200ul, >10^7 TU/mL

MR209340L3V 200 µl Ask for price

Numbl (Myc-DDK-tagged ORF) - Rat numb homolog (Drosophila)-like (Numbl), (10 ug)

RR204216 10 µg Ask for price

Human NUMBL shRNA Plasmid

20-abx956126
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  • 150 µg
  • 300 µg

Mouse NUMBL shRNA Plasmid

20-abx971842
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  • 150 µg
  • 300 µg

NUMBL Recombinant Protein (Rat)

RP214829 100 ug Ask for price

NUMBL (myc-DDK-tagged) - Human numb homolog (Drosophila)-like (NUMBL), transcript variant 2

RC238926 10 µg Ask for price

NUMBL (myc-DDK-tagged) - Human numb homolog (Drosophila)-like (NUMBL), transcript variant 3

RC238927 10 µg Ask for price

NUMBL Recombinant Protein (Mouse)

RP155453 100 ug Ask for price

NUMBL Recombinant Protein (Human)

RP021901 100 ug Ask for price

Rat Numbl / Numb-like protein ELISA Kit

E3117r 96T
EUR 796

Numbl ORF Vector (Rat) (pORF)

ORF071611 1.0 ug DNA
EUR 607.2

Mouse Numb-like protein (NUMBL) ELISA Kit

abx536273-96tests 96 tests
EUR 687.5

Human NUMBL / Numb-like protein ELISA Kit

E3117h 96T
EUR 736

Mouse Numbl / Numb-like protein ELISA Kit

E3117m 96T
EUR 776

NUMBL ORF Vector (Human) (pORF)

ORF007301 1.0 ug DNA
EUR 114

Numbl ORF Vector (Mouse) (pORF)

ORF051819 1.0 ug DNA
EUR 607.2

Lenti ORF particles, NUMBL (mGFP-tagged) - Human numb homolog (Drosophila)-like (NUMBL), 200ul, >10^7 TU/mL

RC216869L2V 200 µl Ask for price

Lenti ORF particles, NUMBL (mGFP-tagged) - Human numb homolog (Drosophila)-like (NUMBL), 200ul, >10^7 TU/mL

RC216869L4V 200 µl Ask for price

Human NUMBL knockout cell line

ABC-KH10433 1 vial Ask for price
Description: Human NUMBL knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human NUMBL knockdown cell line

ABC-KD10433 1 vial Ask for price
Description: Human NUMBL knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Human NUMBL Protein Lysate 20ug

IHUNUMBLPLLY20UG each
EUR 361
Description: Human NUMBL Protein Lysate 20ug

Lenti ORF clone of Numbl (mGFP-tagged ORF) - Rat numb homolog (Drosophila)-like (Numbl), (10 ug)

RR204216L4 10 µg Ask for price

Lenti ORF particles, Numbl (GFP-tagged ORF) - Rat numb homolog (Drosophila)-like (Numbl), 200ul, >10^7 TU/mL

RR204216L4V 200 µl Ask for price

Lenti ORF particles, NUMBL (Myc-DDK tagged) - Human numb homolog (Drosophila)-like (NUMBL), 200ul, >10^7 TU/mL

RC216869L1V 200 µl Ask for price

Lenti ORF particles, NUMBL (Myc-DDK tagged) - Human numb homolog (Drosophila)-like (NUMBL), 200ul, >10^7 TU/mL

RC216869L3V 200 µl Ask for price

Lenti ORF clone of Numbl (Myc-DDK-tagged ORF) - Rat numb homolog (Drosophila)-like (Numbl), (10 ug)

RR204216L3 10 µg Ask for price

Lenti ORF particles, Numbl (Myc-DDK-tagged ORF) - Rat numb homolog (Drosophila)-like (Numbl), 200ul, >10^7 TU/mL

RR204216L3V 200 µl Ask for price

OCOA12958-20UG - NUMBL Protein Lysate

OCOA12958-20UG 20ug
EUR 269

Human Numb- like protein, NUMBL ELISA KIT

ELI-44511h 96 Tests
EUR 988.8

Mouse Numb- like protein, Numbl ELISA KIT

ELI-35534m 96 Tests
EUR 1038

NUMBL 3'UTR GFP Stable Cell Line

TU066094 1.0 ml
EUR 1825.2

Numbl 3'UTR GFP Stable Cell Line

TU164428 1.0 ml Ask for price

Numbl 3'UTR GFP Stable Cell Line

TU264290 1.0 ml Ask for price

Numbl sgRNA CRISPR Lentivector set (Rat)

K7619801 3 x 1.0 ug
EUR 406.8

Numbl sgRNA CRISPR Lentivector set (Mouse)

K4473701 3 x 1.0 ug
EUR 406.8

NUMBL sgRNA CRISPR Lentivector set (Human)

K1467301 3 x 1.0 ug
EUR 406.8

NUMBL Protein Vector (Rat) (pPM-C-HA)

PV286444 500 ng
EUR 723.6

NUMBL Protein Vector (Rat) (pPB-C-His)

PV286442 500 ng
EUR 723.6

NUMBL Protein Vector (Rat) (pPB-N-His)

PV286443 500 ng
EUR 723.6

NUMBL Protein Vector (Rat) (pPM-C-His)

PV286445 500 ng
EUR 723.6

NUMBL Protein Vector (Human) (pPM-C-HA)

PV029203 500 ng Ask for price

NUMBL Protein Vector (Mouse) (pPM-C-HA)

PV207276 500 ng
EUR 723.6

NUMBL Protein Vector (Human) (pPB-C-His)

PV029201 500 ng Ask for price

NUMBL Protein Vector (Human) (pPB-N-His)

PV029202 500 ng Ask for price

NUMBL Protein Vector (Human) (pPM-C-His)

PV029204 500 ng Ask for price

NUMBL Protein Vector (Mouse) (pPB-C-His)

PV207274 500 ng
EUR 723.6

NUMBL Protein Vector (Mouse) (pPB-N-His)

PV207275 500 ng
EUR 723.6

NUMBL Protein Vector (Mouse) (pPM-C-His)

PV207277 500 ng
EUR 723.6

Numbl 3'UTR Luciferase Stable Cell Line

TU114428 1.0 ml Ask for price

Five patients present ocular symptoms on onset. In eight asymptomatic patients remaining, the diagnosis of CMV retinitis is made by screening guided by a positive CMV infection. All patients can be evaluated responding to antivirus treatment but three shows an increase incomplete with the sequel to ocular. Our results show that the incidence of CMV retinitis after the Alogenic HSCT cannot be ignored and active ophthalmological screening is not only based on symptoms but also monitoring positive CMV infection contributes to early diagnosis of CMV retinitis.

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