Default Cytomegalovirus infection (CMV) induces clinical syndrome which is usually associated with hearing loss. However, the effect of CVM infection obtained in adults and children has not been clearly defined. The purpose of this review is to critically assess the scientific evidence of the Association of CMV infection obtained by postnatal or tinnitus hearing loss. Systematic Overview of Records Reporting Sensorineural Loss (SNHL) or Tinnitus and CMV infection obtained including articles published in English is done.

The search strategy is limited to human studies with CMV infection obtained. After screening and quality assessment, nine studies involving 1528 individuals meet inclusion criteria. A total of 14% of patients with SNHL showed evidence of previous exposure to CMV, while in individuals without SNHL (control) percentage rose to 19.3%. SNHL was reported as unilateral or bilateral at 15.3%, and was not determined in 84.7% of cases. SNHL levels range from mild to deep for children and adults. None of the records reported by Tinitus.

The prevalence of children or adults with SNHL acquired by CMV infection obtained confirmed by polymerase chain reaction (PCR) or low IgM anti-CMV antibodies. Fenotyping of patients with CMV infection obtained is limited to hearing loss with pure tone audiometry and no additional audiological tests carried out in most studies. Additional symptoms deserve more attention, including vertigo episodic or tinnitus, because some patients with the clinical spectrum of meniere disease can result from a latent infection of CMV.

Nitrate oxide flows metabolic regulations mediated by a virus during human cytomegalovirus infection

Nitric Oxide is a multipurpose and critical effector molecule that can modulate many cellular functions. Although it is recognized as a regulator of infection, the inhibition mechanism of nitric oxide on human cytomegalovirus replication (HCMV) is still difficult to understand. We show that nitric oxide weakens viral replication by disrupting modulation mediated by HCMV from several cellular processes.

Nitric oxide exposure reduces the synthesis of HCMV genomes and offspring virus infections with differences depending on the type of cell. Mitochondrial respiration greatly reduced both in infected and infected cells HCMV during exposure with a slight impact at the ATP level which shows changes in cellular metabolism. Metabolomics identifies small molecules that change significantly in several routes during exposure to nitrate oxide including nucleotide biosynthesis, tricarboxylic acid cycles (TCA), and glutamine metabolism. Glutathione metabolites increased to coincide with the reduction of glutamine precursor glutathione.

This shift is accompanied by an increase in antioxidant enzymes. Glutamine deprivation imitated defects in HCMV replication and mitochondrial respiration observed during exposure to nitrate oxide. This data shows that nitric oxide limits glutamineolysis by diverting glutamine to glutathione synthesis. In addition, lipid intermediaries are challenuous, which is likely to contribute to the increase in virus particles observed. Nitric Oxide interferes with several cellular processes, and we have limited success in saving defects replication by adding metabolic intermediaries. Our studies show that the ace of nitrate oxide from HCMV is multifactorial with interference with cellular metabolic viruses that play a central role. The importance of human cytomegalovirus is a common pathogen in patients with a compromised immune system, including transplant patients and during innate infections. Lytic HCMV replication is likely to occur on local infection sites with immune cells that infiltrate and release nitrate oxide with other effector molecules.

The clinical results of the recipients of alogenic hematopoietic stem cell transplants develop DNAEMIA CYTOMEGALOVIRUS before the endraftment

There is limited information about the impact of DNAEMIA CMV episodes that develop before the endraftment (pre-cmv dnaemia) in clinical results after alogenic hematopoietic stem cell transplantation (allo-HSCT). This problem is intended for retrospective multicenter studies currently including 878 patients. All participating centers use the preemptive antivirus therapy strategy for prevention of CMV disease. The load of CMV DNA in the blood is monitored by a real-time PCR test. A total of 144 patients (cumulative events were 16.5%, 95% CI, 14% -19%) had a pre-CMV dnaemia episode on the median 10 days after allo-HSCT.

Patients who develop pre-CMV Dnaemia have a significant probability of recurrent episodes (P = <0.001) (50%) than those who experience post-CMV dnaemia (32.9%); However, the incidence of comparable CMV disease (p = 0.52). The cumulative incidence of the overall death (OM) and non-relapse mortality (NRM) at 1 year after the Allo-HSCT was 32% (95% CI, 29-35%) and 23% (95% CI 20-26%), respectively -Masing. The risk of OM and NRM in a customized model emerged proportion to patients who developed a DNAemia CMV episode, regardless of whether it happened before or after the endraftment, in patients with CMV CMV episodes before and post-engraftment or on those without CMV Dnaemia.

Cytomegalovirus Retinitis After transplantation of alogenic hematopoietic stem cells under the active screening of cytomegalovirus antigenemia

Although Cytomegalovirus (CMV) remains a major cause of morbidity and mortality after transplantation of hematopoietic stem cells (HSCT), the incidence of CMV retinitis is considered lower than the incidence of CMV infection in other organs after the shite. In this study, the incidence and characteristics of CMV retinitis were retrospectively evaluated at the Alogenic HSCT receiver. Eye playback is carried out on the development of ocular symptoms or positive CMV infections using peripheral blood evaluated by antigenemia PP65 or a polymerase chain reaction. Of the 514 patients, 13 patients developed CMV retinitis. The median onset of CMV retinitis is day 34 (range, 21-118) post transplants, and cumulative events are 2.5% (95% CI, 1.6-42) at 6 months after transplantation.

anti- NUMBL antibody
FNab05918	FN Test	100µg	EUR 702
Description: Antibody raised against NUMBL

NUMBL Antibody, HRP conjugated
1-CSB-PA897595LB01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

NUMBL Antibody, FITC conjugated
1-CSB-PA897595LC01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

NUMBL Antibody, Biotin conjugated
1-CSB-PA897595LD01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against NUMBL. Recognizes NUMBL from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

NUMBL Conjugated Antibody
C38379	SAB	100ul	EUR 476.4

Polyclonal NUMBL Antibody (N-Term)
AMM06872G	Leading Biology	0.1 mg	EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human NUMBL (N-Term). This antibody is tested and proven to work in the following applications:

Polyclonal NUMBLIKE / NUMBL Antibody (N-Terminus)
AMM06873G	Leading Biology	0.05ml	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human NUMBLIKE / NUMBL (N-Terminus). This antibody is tested and proven to work in the following applications:

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody
abx235917-100ug	Abbexa	100 ug	EUR 577.2

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody
abx235918-100ug	Abbexa	100 ug	EUR 661.2

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody
20-abx334204	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody
20-abx001752	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody
abx117223-100ug	Abbexa	100 ug	EUR 560.4

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody
abx431475-200ul	Abbexa	200 ul	EUR 460.8

Numbl/ Rat Numbl ELISA Kit
ELI-44882r	Lifescience Market	96 Tests	EUR 1063.2

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (HRP)
20-abx336868	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (FITC)
20-abx336869	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

NUMBL Polyclonal Antibody, HRP Conjugated
A70356	EpiGentek	EUR 754.26 EUR 293.70 EUR 470.80	100 ?g 50 ul 100 ul

NUMB Like, Endocytic Adaptor Protein (NUMBL) Antibody (Biotin)
20-abx336870	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

NUMBL Polyclonal Antibody, FITC Conjugated
A70357	EpiGentek	EUR 754.26 EUR 293.70 EUR 470.80	100 ?g 50 ul 100 ul

NUMBL Polyclonal Antibody, Biotin Conjugated
A70358	EpiGentek	EUR 754.26 EUR 293.70 EUR 470.80	100 ?g 50 ul 100 ul

NUMBL siRNA
20-abx926610	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

NUMBL siRNA
20-abx926611	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

NUMBL siRNA
20-abx903703	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

NUMBL Peptide
43-109P	ProSci	0.1 mg	EUR 405.6

NUMBL Rabbit pAb
A2140-100ul	Abclonal	100 ul	EUR 369.6

NUMBL Rabbit pAb
A2140-200ul	Abclonal	200 ul	EUR 550.8

NUMBL Rabbit pAb
A2140-20ul	Abclonal	20 ul	EUR 219.6

NUMBL Rabbit pAb
A2140-50ul	Abclonal	50 ul	EUR 267.6

NUMBL Rabbit pAb
A14088-100ul	Abclonal	100 ul	EUR 369.6

NUMBL Rabbit pAb
A14088-200ul	Abclonal	200 ul	EUR 550.8

NUMBL Rabbit pAb
A14088-20ul	Abclonal	20 ul	EUR 219.6

NUMBL Rabbit pAb
A14088-50ul	Abclonal	50 ul	EUR 267.6

NUMBL cloning plasmid
CSB-CL897595HU-10ug	Cusabio	10ug	EUR 704.4
Description: A cloning plasmid for the NUMBL gene.

NUMBL Blocking Peptide
DF6863-BP	Affbiotech	1mg	EUR 234

NUMBL ELISA KIT|Human
EF001382	Lifescience Market	96 Tests	EUR 826.8

Rat NUMBL shRNA Plasmid
20-abx988573	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Human NUMBL shRNA Plasmid
20-abx956126	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Mouse NUMBL shRNA Plasmid
20-abx971842	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

NUMBL Recombinant Protein (Rat)
RP214829	ABM	100 ug	Ask for price

Numbl ORF Vector (Rat) (pORF)
ORF071611	ABM	1.0 ug DNA	EUR 607.2

NUMBL Recombinant Protein (Human)
RP021901	ABM	100 ug	Ask for price

NUMBL Recombinant Protein (Mouse)
RP155453	ABM	100 ug	Ask for price

NUMBL ORF Vector (Human) (pORF)
ORF007301	ABM	1.0 ug DNA	EUR 114

Numbl ORF Vector (Mouse) (pORF)
ORF051819	ABM	1.0 ug DNA	EUR 607.2

Human Numb- like protein, NUMBL ELISA KIT
ELI-44511h	Lifescience Market	96 Tests	EUR 988.8

Mouse Numb- like protein, Numbl ELISA KIT
ELI-35534m	Lifescience Market	96 Tests	EUR 1038

NUMBL 3'UTR GFP Stable Cell Line
TU066094	ABM	1.0 ml	EUR 1825.2

Numbl 3'UTR GFP Stable Cell Line
TU264290	ABM	1.0 ml	Ask for price

Numbl 3'UTR GFP Stable Cell Line
TU164428	ABM	1.0 ml	Ask for price

Numbl sgRNA CRISPR Lentivector set (Rat)
K7619801	ABM	3 x 1.0 ug	EUR 406.8

Numbl sgRNA CRISPR Lentivector set (Mouse)
K4473701	ABM	3 x 1.0 ug	EUR 406.8

NUMBL sgRNA CRISPR Lentivector set (Human)
K1467301	ABM	3 x 1.0 ug	EUR 406.8

NUMBL Protein Vector (Rat) (pPM-C-HA)
PV286444	ABM	500 ng	EUR 723.6

NUMBL Protein Vector (Rat) (pPB-C-His)
PV286442	ABM	500 ng	EUR 723.6

NUMBL Protein Vector (Rat) (pPB-N-His)
PV286443	ABM	500 ng	EUR 723.6

NUMBL Protein Vector (Rat) (pPM-C-His)
PV286445	ABM	500 ng	EUR 723.6

NUMBL Protein Vector (Human) (pPM-C-HA)
PV029203	ABM	500 ng	Ask for price

NUMBL Protein Vector (Mouse) (pPM-C-HA)
PV207276	ABM	500 ng	EUR 723.6

NUMBL Protein Vector (Human) (pPB-C-His)
PV029201	ABM	500 ng	Ask for price

NUMBL Protein Vector (Human) (pPB-N-His)
PV029202	ABM	500 ng	Ask for price

NUMBL Protein Vector (Human) (pPM-C-His)
PV029204	ABM	500 ng	Ask for price

NUMBL Protein Vector (Mouse) (pPB-C-His)
PV207274	ABM	500 ng	EUR 723.6

NUMBL Protein Vector (Mouse) (pPB-N-His)
PV207275	ABM	500 ng	EUR 723.6

NUMBL Protein Vector (Mouse) (pPM-C-His)
PV207277	ABM	500 ng	EUR 723.6

NUMBL 3'UTR Luciferase Stable Cell Line
TU016094	ABM	1.0 ml	EUR 1825.2

Numbl 3'UTR Luciferase Stable Cell Line
TU114428	ABM	1.0 ml	Ask for price

Numbl 3'UTR Luciferase Stable Cell Line
TU214290	ABM	1.0 ml	Ask for price

Numbl sgRNA CRISPR Lentivector (Rat) (Target 1)
K7619802	ABM	1.0 ug DNA	EUR 184.8

Numbl sgRNA CRISPR Lentivector (Rat) (Target 2)
K7619803	ABM	1.0 ug DNA	EUR 184.8

Numbl sgRNA CRISPR Lentivector (Rat) (Target 3)
K7619804	ABM	1.0 ug DNA	EUR 184.8

Numbl sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4473702	ABM	1.0 ug DNA	EUR 184.8

Numbl sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4473703	ABM	1.0 ug DNA	EUR 184.8

Numbl sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4473704	ABM	1.0 ug DNA	EUR 184.8

NUMBL sgRNA CRISPR Lentivector (Human) (Target 1)
K1467302	ABM	1.0 ug DNA	EUR 184.8

NUMBL sgRNA CRISPR Lentivector (Human) (Target 2)
K1467303	ABM	1.0 ug DNA	EUR 184.8

NUMBL sgRNA CRISPR Lentivector (Human) (Target 3)
K1467304	ABM	1.0 ug DNA	EUR 184.8

Human NUMB Like, Endocytic Adaptor Protein (NUMBL) ELISA Kit
abx381926-96tests	Abbexa	96 tests	EUR 1093.2

NUMBL Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)
LV661351	ABM	1.0 ug DNA	EUR 818.4

NUMBL Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
LV661355	ABM	1.0 ug DNA	EUR 818.4

NUMBL Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)
LV661356	ABM	1.0 ug DNA	EUR 818.4

Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
K7619805	ABM	3 x 1.0 ug	EUR 451.2

Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K4473705	ABM	3 x 1.0 ug	EUR 451.2

NUMBL sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K1467305	ABM	3 x 1.0 ug	EUR 451.2

Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)
K7619806	ABM	1.0 ug DNA	EUR 200.4

Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)
K7619807	ABM	1.0 ug DNA	EUR 200.4

Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)
K7619808	ABM	1.0 ug DNA	EUR 200.4

Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K4473706	ABM	1.0 ug DNA	EUR 200.4

Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K4473707	ABM	1.0 ug DNA	EUR 200.4

Numbl sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K4473708	ABM	1.0 ug DNA	EUR 200.4

NUMBL sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K1467306	ABM	1.0 ug DNA	EUR 200.4

NUMBL sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K1467307	ABM	1.0 ug DNA	EUR 200.4

NUMBL sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K1467308	ABM	1.0 ug DNA	EUR 200.4

NUMBL Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)
LV661352	ABM	1.0 ug DNA	EUR 818.4

NUMBL Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)
LV661353	ABM	1.0 ug DNA	EUR 888

NUMBL Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)
LV661354	ABM	1.0 ug DNA	EUR 888

Anti-NUMBL antibody
PAab05917	Lifescience Market	100 ug	EUR 426

Anti-NUMBL antibody
STJ116023	St John's Laboratory	100 µl	EUR 332.4

Anti-NUMBL antibody
STJ24849	St John's Laboratory	100 µl	EUR 332.4

Anti-NUMBL antibody
STJ70424	St John's Laboratory	100 µg	EUR 430.8

Numb Homolog (NUMB) Antibody
20-abx101020	Abbexa	EUR 510.00 EUR 159.60 EUR 1446.00 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Numb Homolog (NUMB) Antibody
20-abx101021	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

NUMB Antibody
6311-002mg	ProSci	0.02 mg	EUR 206.18
Description: NUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.

NUMB Antibody
6311-01mg	ProSci	0.1 mg	EUR 523.7
Description: NUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.

NUMB Antibody
49415-100ul	SAB	100ul	EUR 399.6

NUMB Antibody
49415-50ul	SAB	50ul	EUR 286.8

NUMB antibody
70R-18998	Fitzgerald	50 ul	EUR 522
Description: Rabbit polyclonal NUMB antibody

NUMB antibody
10R-5100	Fitzgerald	100 ul	EUR 829.2
Description: Mouse monoclonal NUMB antibody

NUMB antibody
10R-5101	Fitzgerald	100 ul	EUR 829.2
Description: Mouse monoclonal NUMB antibody

NUMB antibody
10R-5102	Fitzgerald	100 ul	EUR 829.2
Description: Mouse monoclonal NUMB antibody

NUMB Antibody
25307-100ul	SAB	100ul	EUR 468

NUMB Antibody
ABD7559	Lifescience Market	100 ug	EUR 525.6

NUMB Antibody
35497-100ul	SAB	100ul	EUR 468

NUMB Antibody
36663-100ul	SAB	100ul	EUR 302.4

NUMB Antibody
AF4735	Affbiotech	200ul	EUR 540

NUMB Antibody
1-CSB-PA005466	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against NUMB. Recognizes NUMB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

NUMB Antibody
1-CSB-PA016186DSR2HU	Cusabio	EUR 266.40 EUR 402.00	100ul 50ul
Description: A polyclonal antibody against NUMB. Recognizes NUMB from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

NUMB Antibody
1-CSB-PA016186GA01HU	Cusabio	EUR 716.40 EUR 399.60	150ul 50ul
Description: A polyclonal antibody against NUMB. Recognizes NUMB from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

NUMB Antibody
DF7559	Affbiotech	200ul	EUR 420

NUMB Antibody
1-CSB-PA909836	Cusabio	EUR 380.40 EUR 292.80	100ul 50ul
Description: A polyclonal antibody against NUMB. Recognizes NUMB from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:2000, WB:1:200-1:1000

NUMB Antibody
F41458-0.08ML	NSJ Bioreagents	0.08 ml	EUR 140.25
Description: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

NUMB Antibody
F41458-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene.

Numb Antibody
R31714	NSJ Bioreagents	100 ug	EUR 356.15
Description: Numb is a protein that in humans is encoded by the gene of the same name. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central and peripheral nervous systems. Additionally, the protein product controls binary cell fate decisions in the peripheral and central nervous systems of both invertebrates and mammals during neurogenesis.

NUMB Antibody
R35011-100UG	NSJ Bioreagents	100 ug	EUR 339.15
Description: Additional name(s) for this target protein: Protein S171

anti- NUMB antibody
FNab05913	FN Test	100µg	EUR 658.5
Description: Antibody raised against NUMB

anti- NUMB antibody
FNab05914	FN Test	100µg	EUR 658.5
Description: Antibody raised against NUMB

anti- NUMB antibody
FNab05915	FN Test	100µg	EUR 658.5
Description: Antibody raised against NUMB

anti- NUMB antibody
FNab05916	FN Test	100µg	EUR 702
Description: Antibody raised against NUMB

Numb Homolog (NUMB) Polyclonal Antibody (Mouse)
4-PAJ934Mu01	Cloud-Clone	EUR 301.20 EUR 3091.20 EUR 768.00 EUR 379.20 EUR 258.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Numb Homolog (NUMB)

NUMB, Endocytic Adaptor Protein (NUMB) Antibody
20-abx214294	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

NUMB, Endocytic Adaptor Protein (NUMB) Antibody
abx235913-100ug	Abbexa	100 ug	EUR 610.8

NUMB, Endocytic Adaptor Protein (NUMB) Antibody
abx235914-100ug	Abbexa	100 ug	EUR 610.8

NUMB, Endocytic Adaptor Protein (NUMB) Antibody
abx235915-100ug	Abbexa	100 ug	EUR 610.8

NUMB, Endocytic Adaptor Protein (NUMB) Antibody
abx235916-100ug	Abbexa	100 ug	EUR 661.2

NUMB, Endocytic Adaptor Protein (NUMB) Antibody
20-abx327629	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

NUMB, Endocytic Adaptor Protein (NUMB) Antibody
20-abx322626	Abbexa	EUR 526.80 EUR 393.60	100 ul 50 ul

NUMB, Endocytic Adaptor Protein (NUMB) Antibody
20-abx123996	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Five patients present ocular symptoms on onset. In eight asymptomatic patients remaining, the diagnosis of CMV retinitis is made by screening guided by a positive CMV infection. All patients can be evaluated responding to antivirus treatment but three shows an increase incomplete with the sequel to ocular. Our results show that the incidence of CMV retinitis after the Alogenic HSCT cannot be ignored and active ophthalmological screening is not only based on symptoms but also monitoring positive CMV infection contributes to early diagnosis of CMV retinitis.