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Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit to Drive Glycolytic Activation and Support Productive Viral Infection
The human cytomegalovirus infection (HCMV) modulates cellular metabolism to support viral replication. Kinase Kinase Kinase Calcium / Calmodulin (CAMKK) and Protein activated amp (AMPK) regulates metabolic activation and has been found important for successful HCMV infections. Here, we explore the specific contributions of camkk isoforms and ampk subunit isoforms to make HCMV infection. Our results show that various ISOFORM camkk and AMPK contribute to infection in a unique way.
For example, Camkk1 is important for HCMV infection in low infection multiplicity, but can be used for AMPK activation during the earliest infection, which is suggested by our data more dependent on camkk2. Our results also show that HCMV specifically induces the expression of catalytic subunit ampka2 non-ubiquitous, which is found important for glycolytic activation mediated by HCMV and high titers infections. Furthermore, we found that glycolytic activation mediated ampk was important for infection, as an excessive expression of glut4, high-capacity glucose transporter, some saved viral replication in the face of the inhibition of Ampk.
Collectively, our data shows that HCMV infection selectively induces specific metabolic regulation kinase expression, relying on their activities to support glycolytic activation and productive infection. The important virus is a mandatory parasite to provide energy and molecular building blocks to the masses to produce a descendant of the infectious virus. The process that regulates the modulation of cellular resource viruses has emerged as critical for successful infections.
Here, we find that HCMV depends on two kinase isoforms to support infection, camkk1 and ampka2. We found that HCMV specifically induces ampka2 subunit expression to induce metabolic activation and encourage strong viral replication. These results indicate that HCMV has evolved a mechanism to target certain metabolic regulatory kinase subunits to support productive infections, thus providing insight into how HCMV hijacked cellular metabolism for replication, and explained the vulnerability of potential virus therapy.
Cytomegalovirus cervical reactivation, cytokine, and spontaneous premature birth in Kenyan women
Activation of cytomegalovirus genital reactivation (CMV) is common during the third trimester of pregnancy. We hypothesize, cervical CMV shedding can increase the risk of spontaneous premature birth (SPTB) through the release of inflammatory cytokines in the cervix. We conducted a nesting case control analysis to determine the relationship between shedding CMV and SPTB using data and samples from prospective cohort studies in West Kenya. Women delivered between 28 + 0 and 33 + 6 weeks of pregnancy are adjusted to the gestational age on the collection of samples to control delivered ≥37 + 0 weeks.
The Level of CMV DNA and Interleukin (IL) -1 Beta (β), IL-6, IL-8, and Necrosis Factor-Alpha (TNF-α) tumors are measured in the servix. We use conditional logistic regression to assess the relationship between shedding cmv, cervical cytokine levels, and SPTB. Among the 86 cases and 86 suitable controls, cmv cervical levels are not significantly related to the SPTB (Odds Ratio [or] = 1.23, 95% trust interval [CI] 0.59-2.56), but significantly associated With higher IL-6 cervical levels. (β = 0.15, 95% CI 0.02-0.29) and TNF-α (β = 0.14, 95% CI 0.01-0.27). In univariate analysis, higher SPTB opportunities are associated with higher cervical IL-6 levels (or = 1.54, 95% CI 1.00-2.38), but not with other cervical cytokines. In this Kenyan women’s cohort, we did not find a significant relationship between cervical and SPTB shedding before 34 weeks.
Letermovir prophylaxis is effective in preventing reactivation of cytomegalovirus after alogenic hematopoietic cell transplantation: real single world data data
Morbidity and mortality after alogenic hematopoietic cell transplants (ALLOHCT) are still basically influenced by Cytomegalovirus (CMV) reactivation. We evaluate 80 seropositive patients transplanted in a row between March 2018 and March 2019 who received the prophylaxis of the Letermovir (leave) from engraftment to day +100 and retrospectively compare it with 80 patients without allowing allograft between January 2017 and March 2018.
The end point of research This is a cumulative incidence (CI) Clinically significant CMV infection (CS-CMVI) defined as CMV reactivation which demands preemptive treatment or CMV disease. With 14% CI CS-CMVI on the day +100 (11 events) significantly lower in let the cohort compared to the control group (33 events, 41%; HR 0.29; p <0.001). While therapy with Foscarnet can be fully avoided in the Group Leave, 7 out of 80 patients in the control cohort receiving Foscarnet, producing 151 extra patients for foscarnet (p = 0.002). The overall survival of one year is 72% on the control arm vs. 84% in the arms (HR 0.75 [95% CI 0.43-1.30]; P <0.306). This study confirms the efficacy and security let’s for the CS-CMVI prophylaxis after ALLOHCT in real-world settings, resulting in significant patient benefits by reducing hospitalization needs and exposure to antivirus drugs that are potentially toxic for the treatment of CMV reactivation.

Micrornas screening and validation and targets expressly expressed in hypertensive mice caused by cytomegalovirus infection
Introduction Some studies have suggested the relationship between Cytomegalovirus (CMV) infection and essential hypertension (eh). Micrornas (MIRNAS) plays an important role in developing EH by regulating specific target gene expression. However, a few are known about the role of MIRNA in uh induced by CMV. In this study, we compare the profile of Mirna’s expressions from samples from normal and murine cytomegalovirus (MCMV) -Infected C57BL / 6 mice using high-throughput sequencing analysis.
The method we collect thoracic aortic, heart tissue, and peripheral blood of twenty normal mice and twenty mice infected with MCMV. We identify Mirna which is expressly expressed in peripheral blood samples and predicts their target genes using bioinformatics tools. We then experimentally validated them using QRT-PCR and target genes with a double luciferase gene test test. The results we found 118 expressed by MIRNAs, including 9 MIRNAs was identified as potential hypertensive regulators induced by MCMV infection. We then validated the expression of two MIRAS candidates, MMU-MIR-1929-3P and MCMV-MIR-M01-4-5P, using QRT-PCR.
FBXO17 Blocking Peptide |
DF13006-BP |
Affbiotech |
1mg |
EUR 234 |
FBXO17 cloning plasmid |
CSB-CL853409HU-10ug |
Cusabio |
10ug |
EUR 411.6 |
|
Description: A cloning plasmid for the FBXO17 gene. |
Polyclonal Goat anti-GST α-form |
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 336 |
Polyclonal Goat anti-GST μ-form |
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 336 |
Polyclonal Goat anti-GST p-form |
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 336 |
Human FBXO17 shRNA Plasmid |
20-abx964438 |
Abbexa |
|
|
|
Mouse FBXO17 shRNA Plasmid |
20-abx974104 |
Abbexa |
|
|
|
Rat FBXO17 shRNA Plasmid |
20-abx988576 |
Abbexa |
|
|
|
FBXO17 Recombinant Protein (Human) |
RP011875 |
ABM |
100 ug |
Ask for price |
FBXO17 Recombinant Protein (Rat) |
RP200984 |
ABM |
100 ug |
Ask for price |
FBXO17 Recombinant Protein (Mouse) |
RP133955 |
ABM |
100 ug |
Ask for price |
F-Box Protein 17 (FBXO17) Antibody |
abx233038-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
Fbxo17 ORF Vector (Rat) (pORF) |
ORF066996 |
ABM |
1.0 ug DNA |
EUR 607.2 |
FBXO17 ORF Vector (Human) (pORF) |
ORF003959 |
ABM |
1.0 ug DNA |
EUR 114 |
Fbxo17 ORF Vector (Mouse) (pORF) |
ORF044653 |
ABM |
1.0 ug DNA |
EUR 607.2 |
FBXO17 sgRNA CRISPR Lentivector set (Human) |
K0764701 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
Fbxo17 sgRNA CRISPR Lentivector set (Mouse) |
K4857601 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
Fbxo17 sgRNA CRISPR Lentivector set (Rat) |
K6558001 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
FBXO17 sgRNA CRISPR Lentivector (Human) (Target 1) |
K0764702 |
ABM |
1.0 ug DNA |
EUR 184.8 |
FBXO17 sgRNA CRISPR Lentivector (Human) (Target 2) |
K0764703 |
ABM |
1.0 ug DNA |
EUR 184.8 |
FBXO17 sgRNA CRISPR Lentivector (Human) (Target 3) |
K0764704 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxo17 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
K4857602 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxo17 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
K4857603 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxo17 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
K4857604 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxo17 sgRNA CRISPR Lentivector (Rat) (Target 1) |
K6558002 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxo17 sgRNA CRISPR Lentivector (Rat) (Target 2) |
K6558003 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Fbxo17 sgRNA CRISPR Lentivector (Rat) (Target 3) |
K6558004 |
ABM |
1.0 ug DNA |
EUR 184.8 |
FBXO17 Protein Vector (Human) (pPB-C-His) |
PV015833 |
ABM |
500 ng |
EUR 394.8 |
FBXO17 Protein Vector (Human) (pPB-N-His) |
PV015834 |
ABM |
500 ng |
EUR 394.8 |
FBXO17 Protein Vector (Human) (pPM-C-HA) |
PV015835 |
ABM |
500 ng |
EUR 394.8 |
FBXO17 Protein Vector (Human) (pPM-C-His) |
PV015836 |
ABM |
500 ng |
EUR 394.8 |
FBXO17 Protein Vector (Mouse) (pPB-C-His) |
PV178610 |
ABM |
500 ng |
EUR 723.6 |
FBXO17 Protein Vector (Mouse) (pPB-N-His) |
PV178611 |
ABM |
500 ng |
EUR 723.6 |
FBXO17 Protein Vector (Mouse) (pPM-C-HA) |
PV178612 |
ABM |
500 ng |
EUR 723.6 |
FBXO17 Protein Vector (Mouse) (pPM-C-His) |
PV178613 |
ABM |
500 ng |
EUR 723.6 |
FBXO17 3'UTR Luciferase Stable Cell Line |
TU007783 |
ABM |
1.0 ml |
EUR 2799.6 |
Fbxo17 3'UTR GFP Stable Cell Line |
TU254497 |
ABM |
1.0 ml |
Ask for price |
Fbxo17 3'UTR Luciferase Stable Cell Line |
TU106413 |
ABM |
1.0 ml |
Ask for price |
FBXO17 3'UTR GFP Stable Cell Line |
TU057783 |
ABM |
1.0 ml |
EUR 2799.6 |
Fbxo17 3'UTR Luciferase Stable Cell Line |
TU204497 |
ABM |
1.0 ml |
Ask for price |
Fbxo17 3'UTR GFP Stable Cell Line |
TU156413 |
ABM |
1.0 ml |
Ask for price |
FBXO17 Protein Vector (Rat) (pPB-C-His) |
PV267982 |
ABM |
500 ng |
EUR 723.6 |
FBXO17 Protein Vector (Rat) (pPB-N-His) |
PV267983 |
ABM |
500 ng |
EUR 723.6 |
FBXO17 Protein Vector (Rat) (pPM-C-HA) |
PV267984 |
ABM |
500 ng |
EUR 723.6 |
FBXO17 Protein Vector (Rat) (pPM-C-His) |
PV267985 |
ABM |
500 ng |
EUR 723.6 |
Human F-Box Protein 17 (FBXO17) ELISA Kit |
abx387316-96tests |
Abbexa |
96 tests |
EUR 1093.2 |
|
FBXO17 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV) |
LV665293 |
ABM |
1.0 ug DNA |
EUR 616.8 |
FBXO17 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC) |
LV665297 |
ABM |
1.0 ug DNA |
EUR 616.8 |
FBXO17 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a) |
LV665298 |
ABM |
1.0 ug DNA |
EUR 616.8 |
Goat F box only protein 17(FBXO17) ELISA kit |
E06F0279-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Goat F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat F box only protein 17(FBXO17) ELISA kit |
E06F0279-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Goat F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Goat F box only protein 17(FBXO17) ELISA kit |
E06F0279-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Goat F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit F box only protein 17(FBXO17) ELISA kit |
E04F0279-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit F box only protein 17(FBXO17) ELISA kit |
E04F0279-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rabbit F box only protein 17(FBXO17) ELISA kit |
E04F0279-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rabbit F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse F box only protein 17(FBXO17) ELISA kit |
E03F0279-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Mouse F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse F box only protein 17(FBXO17) ELISA kit |
E03F0279-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Mouse F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse F box only protein 17(FBXO17) ELISA kit |
E03F0279-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Mouse F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig F box only protein 17(FBXO17) ELISA kit |
E07F0279-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Porcine F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig F box only protein 17(FBXO17) ELISA kit |
E07F0279-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Porcine F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Pig F box only protein 17(FBXO17) ELISA kit |
E07F0279-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Porcine F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog F box only protein 17(FBXO17) ELISA kit |
E08F0279-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Canine F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog F box only protein 17(FBXO17) ELISA kit |
E08F0279-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Canine F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Dog F box only protein 17(FBXO17) ELISA kit |
E08F0279-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Canine F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey F box only protein 17(FBXO17) ELISA kit |
E09F0279-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Monkey F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey F box only protein 17(FBXO17) ELISA kit |
E09F0279-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Monkey F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Monkey F box only protein 17(FBXO17) ELISA kit |
E09F0279-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Monkey F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat F box only protein 17(FBXO17) ELISA kit |
E02F0279-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Rat F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat F box only protein 17(FBXO17) ELISA kit |
E02F0279-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Rat F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Rat F box only protein 17(FBXO17) ELISA kit |
E02F0279-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Rat F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human F- box only protein 17, FBXO17 ELISA KIT |
ELI-48580h |
Lifescience Market |
96 Tests |
EUR 988.8 |
Human F box only protein 17(FBXO17) ELISA kit |
E01F0279-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Human F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human F box only protein 17(FBXO17) ELISA kit |
E01F0279-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Human F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Human F box only protein 17(FBXO17) ELISA kit |
E01F0279-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Human F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Mouse F- box only protein 17, Fbxo17 ELISA KIT |
ELI-12874m |
Lifescience Market |
96 Tests |
EUR 1038 |
Guinea pig F box only protein 17(FBXO17) ELISA kit |
E05F0279-192T |
BlueGene |
192 tests |
EUR 1524 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig F box only protein 17(FBXO17) ELISA kit |
E05F0279-48 |
BlueGene |
1 plate of 48 wells |
EUR 624 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
Guinea pig F box only protein 17(FBXO17) ELISA kit |
E05F0279-96 |
BlueGene |
1 plate of 96 wells |
EUR 822 |
|
Description: A competitive ELISA for quantitative measurement of Guinea pig F box only protein 17(FBXO17) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
FBXO17 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
K0764705 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
Fbxo17 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse) |
K4857605 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
Fbxo17 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat) |
K6558005 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
FBXO17 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA) |
LV665294 |
ABM |
1.0 ug DNA |
EUR 616.8 |
FBXO17 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro) |
LV665295 |
ABM |
1.0 ug DNA |
EUR 686.4 |
FBXO17 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro) |
LV665296 |
ABM |
1.0 ug DNA |
EUR 686.4 |
FBXO17 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
K0764706 |
ABM |
1.0 ug DNA |
EUR 200.4 |
FBXO17 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
K0764707 |
ABM |
1.0 ug DNA |
EUR 200.4 |
FBXO17 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
K0764708 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxo17 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1) |
K4857606 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxo17 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2) |
K4857607 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxo17 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3) |
K4857608 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxo17 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1) |
K6558006 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxo17 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2) |
K6558007 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Fbxo17 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3) |
K6558008 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Anti-Anti-SEPT6 antibody antibody |
STJ11100949 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. |
Anti-Anti-SEPT9 Antibody antibody |
STJ111369 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described. |
Anti-Anti-SEPT4 Antibody antibody |
STJ112276 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. |
Anti-Anti-SEPT5 Antibody antibody |
STJ114819 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
Anti-Anti-SEPT7 Antibody antibody |
STJ116214 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
Anti-Anti-SEPT8 Antibody antibody |
STJ117206 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Anti-Anti-SEPT12 Antibody antibody |
STJ117759 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. |
Anti-Anti-SEPT7 Antibody antibody |
STJ28963 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
Anti-Anti-SEPT5 Antibody antibody |
STJ25477 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
Anti-Anti-SEPT8 Antibody antibody |
STJ25479 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Anti-Anti-SEPT1 antibody antibody |
STJ119580 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012] |
Anti-Anti-DDB1 Antibody |
A00333 |
BosterBio |
100uL |
EUR 546 |
Description: Rabbit Polyclonal DDB1 Antibody. Validated in IP and tested in Human, Mouse. |
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
AEA465Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 6777.36 |
|
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
AEA465Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 663.31 |
|
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
AEA465Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 896.16 |
|
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
AEA465Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3672.72 |
|
Description: This is Competitive Enzyme-linked immunosorbent assay for Antibody Detection.detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in serum, plasma and other biological fluids. |
Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) ELISA Kit |
4-AEA465Hu |
Cloud-Clone |
-
EUR 6837.60
-
EUR 3613.20
-
EUR 896.40
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Anti-Anti-Sperm Antibody Antibody (Anti-AsAb) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. |
ELISA kit for Human Anti-AsAb (Anti-Anti-Sperm Antibody Antibody) |
ELK8071 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
Description: A competitive Inhibition ELISA kit for detection of Anti-Anti-Sperm Antibody Antibody from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
Anti-ZNF660 antibody |
44742-100ul |
SAB |
100ul |
EUR 302.4 |
Anti-ZNF660 antibody |
44742-50ul |
SAB |
50ul |
EUR 224.4 |
Anti-CCV Antibody |
10-2789 |
Fitzgerald |
1 mg |
EUR 217.2 |
Description: Anti-Canine Corona Virus Antibody |
Anti-CCV Antibody |
10-2790 |
Fitzgerald |
1 mg |
EUR 217.2 |
Description: Anti-Canine Corona Virus Antibody |
Anti-CDV antibody |
10-2791 |
Fitzgerald |
1 mg |
EUR 198 |
Description: Anti-Canine Distemper Virus antibody |
Anti-CDV antibody |
10-2792 |
Fitzgerald |
1 mg |
EUR 198 |
Description: Anti-Canine Distemper Virus antibody |
Anti-CDV antibody |
10-2793 |
Fitzgerald |
1 mg |
EUR 198 |
Description: Anti-Canine Distemper Virus antibody |
Anti-CDV antibody |
10-2794 |
Fitzgerald |
1 mg |
EUR 198 |
Description: Anti-Canine Distemper Virus antibody |
Anti-CPV Antibody |
10-2795 |
Fitzgerald |
500 uig |
EUR 165.6 |
Description: Anti-Canine Parvo Virus Antibody |
Anti-CPV Antibody |
10-2796 |
Fitzgerald |
500 ug |
EUR 165.6 |
Description: Anti-Canine Parvo Virus Antibody |
Anti-CPV Antibody |
10-2797 |
Fitzgerald |
500 ug |
EUR 165.6 |
Description: Anti-Canine Parvo Virus Antibody |
Anti-C.CRP antibody |
10-2798 |
Fitzgerald |
500 ug |
EUR 165.6 |
Description: Anti-Canine CRP antibody |
Anti-C.CRP antibody |
10-2799 |
Fitzgerald |
500 ug |
EUR 165.6 |
Description: Anti-Canine CRP antibody |
Anti-CHW antibody |
10-2800 |
Fitzgerald |
1 mg |
EUR 198 |
Description: Anti-Canine Heartworm antibody |
Anti-FeLV antibody |
10-2801 |
Fitzgerald |
1 mg |
EUR 217.2 |
Description: Anti-Feline Leukemia Virus antibody |
Anti-FeLV antibody |
10-2802 |
Fitzgerald |
1 mg |
EUR 217.2 |
Description: Anti-Feline Leukemia Virus antibody |
Anti-FeLV antibody |
10-2803 |
Fitzgerald |
1 mg |
EUR 217.2 |
Description: Anti-Feline Leukemia Virus antibody |
Anti-PGI antibody |
10-2806 |
Fitzgerald |
1 mg |
EUR 502.8 |
Description: Anti-PGI recombinant antibody |
Anti-PGI antibody |
10-2807 |
Fitzgerald |
1 mg |
EUR 502.8 |
Description: Anti-PGI recombinant antibody |
Anti-PGII antibody |
10-2808 |
Fitzgerald |
1 mg |
EUR 502.8 |
Description: Anti-PGII recombinant antibody |
Anti-PGII antibody |
10-2809 |
Fitzgerald |
1 mg |
EUR 502.8 |
Description: Anti-PGII recombinant antibody |
Anti-CHW antibody |
10-2810 |
Fitzgerald |
1 mg |
EUR 198 |
Description: Anti-CHW monoclonal antibody |
Anti-Giardia antibody |
10-2811 |
Fitzgerald |
1 mg |
EUR 198 |
Description: Anti-Giardia monoclonal antibody |
Anti-Giardia antibody |
10-2812 |
Fitzgerald |
1 mg |
EUR 198 |
Description: Anti-Giardia monoclonal antibody |
Anti-TAP1 Antibody |
A01123 |
BosterBio |
100ul |
EUR 476.4 |
Description: Rabbit Polyclonal TAP1 Antibody. Validated in IP, IHC, WB and tested in Human, Rat. |
Anti-CHD4 Antibody |
A01125 |
BosterBio |
100ul |
EUR 476.4 |
Description: Rabbit Polyclonal CHD4 Antibody. Validated in IF, IHC and tested in Human, Mouse. |
Anti-NRF1 Antibody |
A01129-2 |
BosterBio |
100ug/vial |
EUR 400.8 |
Anti-MEF2C Antibody |
A01131-1 |
BosterBio |
100ug/vial |
EUR 400.8 |
Anti-SCN4A Antibody |
A01138 |
BosterBio |
100ul |
EUR 476.4 |
Description: Rabbit Polyclonal SCN4A Antibody. Validated in WB and tested in Human. |
Anti-MTR Antibody |
A01140-2 |
BosterBio |
100ug/vial |
EUR 400.8 |
Anti-IL12B Antibody |
A01152-2 |
BosterBio |
100ug/vial |
EUR 352.8 |
Anti-IL12B Antibody |
A01152-3 |
BosterBio |
100ug/vial |
EUR 400.8 |
Anti-IL12B Antibody |
A01152-4 |
BosterBio |
100ug/vial |
EUR 352.8 |
Anti-IL11 Antibody |
A01160-1 |
BosterBio |
100ug/vial |
EUR 352.8 |
Anti-Bak Antibody |
A01163 |
BosterBio |
200ug |
EUR 626.4 |
Description: Rabbit Polyclonal Bak Antibody. Validated in IP, IF, IHC, WB and tested in Human. |
Anti-PGF Antibody |
A01164-1 |
BosterBio |
100ug/vial |
EUR 352.8 |
Anti-PGF Antibody |
A01164-2 |
BosterBio |
100ug/vial |
EUR 352.8 |
Anti-CD201 Antibody |
A01166 |
BosterBio |
100ul |
EUR 476.4 |
Description: Rabbit Polyclonal Antibody for CD201 Antibody (PROCR) detection.tested for IHC, WB in Human, Mouse, Rat. |
Anti-SERCA2 Antibody |
A01176 |
BosterBio |
100ul |
EUR 476.4 |
Description: Rabbit Polyclonal Antibody for SERCA2 Antibody (ATP2A2) detection.tested for IHC, WB in Human, Mouse, Rat. |
Anti-XPA Antibody |
A01182 |
BosterBio |
100ul |
EUR 476.4 |
Description: Rabbit Polyclonal XPA Antibody. Validated in IHC, WB and tested in Human. |
Anti-XPA Antibody |
A01182-1 |
BosterBio |
100ul |
EUR 476.4 |
Description: Rabbit Polyclonal Antibody for XPA Antibody (XPA) detection.tested for WB in Human, Mouse. |
Anti-XPA Antibody |
A01182-2 |
BosterBio |
100ug/vial |
EUR 352.8 |
Furthermore, the dual-luciferase reporter gene test revealed that the area 3′-untranslated (UTR) endothelin A receptor (Ednra) MRNA contains a binding site for MMU-MIR-1929-3P. Collectively, our data shows that MCMV infection can increase blood pressure and reduce MMU-MIR-1929-3P expression in C57BL / 6. In addition, we find that MMU-MIR-1929-3P targets 3 ‘UTR from MRNA Ednra. Conclusion This new regulation axis can help develop a new approach to clinical prevention and control eh.