Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes

Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes

Background: Human cytomegalovirus (HCMV) causes no symptoms, but also cause congenital infection when HCMV-infected women during pregnancy, and life-threatening disease in immunocompromised patients. To better understand the mechanism of neutralization activity against HCMV, HCMV antibody titers association NT judged by antibody titers against each glycoprotein complex (gc) of HCMV.


Methods: Sera were collected from 78 healthy adult volunteers were used. Merlin HCMV HCMV clinical isolates strain and 1612 strain used in the NT test with plaque reduction test, in which both the MRC-5 fibroblasts cells and RPE-1 epithelial cells are used. Complex glycoprotein gB, gH / gL complex (gH / gL / GO and gH / gL / UL128-131A [PC]) and GM / GN selected as the target glycoprotein. 293FT cells expressed with gB, GM / gn, gH / gL / GO, or PC, is prepared and used for the measurement of antibody titers against each gc in an indirect immunofluorescence assay (IIFA). The correlation between titer IIFA for every gc and HCMV-NT titers evaluated.


Results: No significant correlation between specific titer IIFA gB and HCMV-NT titers in the epithelial cells or between GM / GN specific complex titer and titer IIFA HCMV-NT. On the other hand, there is a positive correlation statistically significant between the titer IIFA for complex gH / gL and the titer of HCMV-NT.

Conclusion: The data show that the complex of gH / gL may be a prime target for inducing activity against HCMV NT.

 Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes
Association of human cytomegalovirus (HCMV) neutralizing antibodies with antibodies to the HCMV glycoprotein complexes

Based Necroptosis CRISPR screen Neuropilin-1 knockout revealed as the host factors important for the early stages of murine cytomegalovirus infection

The herpes virus is a human pathogen everywhere which causes various health complications. Currently, there is an incomplete understanding of the cellular factors that contribute to the herpes virus infection. Here, we report the antivirus necroptosis based genetic screen to identify factors of new host cells is required for β-herpes virus infection of murine cytomegalovirus (MCMV).

screen-based genome-wide CRISPR we utilized the capacity of the mutant herpes virus that triggers cell death necroptotic antivirus virus early gene expression. Vascular endothelial growth factor (VEGF) and semaphorin receptor binding Neuropilin-1 (Nrp-1) has emerged as an important determinant of MCMV infection. We found that the removal of damage early Nrp-1 virus gene expression and reduce the rate of infection in endothelial cells, fibroblasts and macrophages. Furthermore, preincubation with soluble Nrp virus-1 infection by reducing dramatically inhibit virus attachment. Thus, Nrp-1 is a major determinant of the initial phase of MCMV infection.

p38 Antibody

20-abx133223
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

20-abx007541
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

p38 Antibody

abx236076-100ug 100 ug
EUR 577.2

p38 protein

E20-80078 20ug
EUR 489.6

p38 protein

E20-80079 20ug
EUR 489.6

anti-p38

YF-PA23519 50 ul
EUR 400.8
Description: Mouse polyclonal to p38

anti-p38

YF-PA23520 50 ul
EUR 400.8
Description: Mouse polyclonal to p38

anti-p38

YF-PA23521 50 ul
EUR 400.8
Description: Mouse polyclonal to p38

anti-p38

YF-PA11120 50 ug
EUR 435.6
Description: Mouse polyclonal to p38

anti-p38

YF-PA11121 100 ug
EUR 483.6
Description: Rabbit polyclonal to p38

PM 102

B5517-1 1 mg
EUR 721.2

MM-102

B1582-2 2 mg
EUR 153.6
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-20 20 mg
EUR 711.6
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B1582-5 5 mg
EUR 254.4
Description: MM-102 is an antagonist of MLL1 with IC50 value of 2.4nM [1].Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase.

MM-102

B2364-25
EUR 705.6

MM-102

B2364-5
EUR 222

PPQ-102

B3504-10 10 mg
EUR 290.4

PPQ-102

B3504-5 5 mg
EUR 181.2

PPQ-102

B3504-50 50 mg
EUR 1035.6

PPQ-102

HY-14179 100mg
EUR 1465.2

BGB-102

HY-15732 10mg
EUR 7249.2

EL-102

HY-16187 10mM/1mL
EUR 451.2

LSZ-102

HY-111486 50mg
EUR 3985.2

MM-102

HY-12220 10mg
EUR 357.6

IAXO-102

HY-125171 50mg
EUR 2332.8

5(6)-FAM [5-(and-6)-Carboxyfluorescein] *CAS 72088-94-9*

102 25 g
EUR 1051.2

SB-203580 p38 MAPK(p38 MAP kinase) Inhibitor

E1B1863 1mg
EUR 193.2

p38 MAPK antibody

10R-8422 100 ul
EUR 471.6
Description: Mouse monoclonal p38 MAPK antibody

P38 MAPK antibody

70R-34325 100 ug
EUR 392.4
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

70R-34327 100 ug
EUR 392.4
Description: Rabbit polyclonal P38 MAPK antibody

p38 MAPK antibody

70R-33398 100 ug
EUR 392.4
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

70R-33400 100 ug
EUR 392.4
Description: Rabbit polyclonal p38 MAPK antibody

P38 delta protein

30R-2868 5 ug
EUR 603.6
Description: Purified recombinant Human P38 delta protein

p38 alpha protein

30R-2870 5 ug
EUR 603.6
Description: Purified recombinant Human p38 alpha protein

p38 beta protein

30R-2875 5 ug
EUR 603.6
Description: Purified recombinant Human p38 beta protein

p38 Polyclonal Antibody

41305-100ul 100ul
EUR 302.4

p38 Polyclonal Antibody

41305-50ul 50ul
EUR 224.4

p38 Polyclonal Antibody

41306-100ul 100ul
EUR 302.4

p38 Polyclonal Antibody

41306-50ul 50ul
EUR 224.4

p38 MAPK Antibody

49379-100ul 100ul
EUR 399.6

p38 MAPK Antibody

49379-50ul 50ul
EUR 286.8

p38 MAPK antibody

20R-2950 100 ul
EUR 471.6
Description: Rabbit polyclonal p38 MAPK antibody

p38 MAPK antibody

20R-1572 100 ug
EUR 846
Description: Rabbit polyclonal p38 MAPK antibody

P38 MAPK antibody

20R-2087 50 ug
EUR 337.2
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2088 50 ug
EUR 337.2
Description: Rabbit polyclonal P38 MAPK antibody

P38 MAPK antibody

20R-2403 50 ug
EUR 337.2
Description: Rabbit polyclonal P38 MAPK antibody

p38 (pY323) Antibody

20-abx133058
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

p38 (pY182) Antibody

20-abx134951
  • EUR 460.80
  • EUR 727.20
  • EUR 276.00
  • 100 ul
  • 200 ul
  • 30 ul

p38 Blocking Peptide

20-abx161932
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

p38 Polyclonal Antibody

ABP52112-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52112-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182

p38 Polyclonal Antibody

ABP52113-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP52113-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323

p38 Polyclonal Antibody

ABP53838-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53838-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180

p38 Polyclonal Antibody

ABP53839-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP53839-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182

p38 Polyclonal Antibody

ABP57354-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Polyclonal Antibody

ABP57354-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38

p38 Blocking Peptide

20-abx061736
  • EUR 309.60
  • EUR 460.80
  • 1 mg
  • 5 mg

p38 Blocking Peptide

20-abx062080
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

p38 (pT180) Antibody

20-abx009863
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

p38 MAPK Antibody

20-abx012798
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

p38 MAPK Antibody

20-abx012875
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

p38 MAPK Antibody

ABF6456 100 ug
EUR 525.6

p38 MAPK Antibody

abx236077-100ug 100 ug
EUR 577.2

p38 beta, Active

7763-100
EUR 5214

p38 beta, Active

7763-5
EUR 444

Anti-p38 Antibody

A00176 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for p38 Antibody (MAPK14) detection.tested for WB in Human, Mouse, Rat.

Anti-p38 alpha

DB-1039 100 tests
EUR 568.8

Anti-p38 beta

DB-1040 100 tests
EUR 568.8

Anti-p38 gamma

DB-1041 100 tests
EUR 568.8

Anti-p38 delta

DB-1042 100 tests
EUR 568.8

Anti-p38-a

DB-161-0.05 50 μl
EUR 322.8

Anti-p38-a

DB-161-0.1 100 μl
EUR 506.4

Anti-p38-b

DB-162-0.05 50 μl
EUR 322.8

Anti-p38-b

DB-162-0.1 100 μl
EUR 506.4

Anti-p38-g

DB-163-0.05 50 μl
EUR 322.8

Anti-p38-g

DB-163-0.1 100 μl
EUR 506.4

Anti-p38-d

DB-164-0.05 50 μl
EUR 322.8

Anti-p38-d

DB-164-0.1 100 μl
EUR 506.4

Anti-p38 alpha

DB1039 100 tests
EUR 568.8

Anti-p38 beta

DB1040 100 tests
EUR 568.8

Anti-p38 gamma

DB1041 100 tests
EUR 568.8

Anti-p38 delta

DB1042 100 tests
EUR 568.8

AIMP2/p38 Antibody

DF12048 200ul
EUR 420

Crk p38 Antibody

AF6323 200ul
EUR 420

p38 MAPK Antibody

AF6455 200ul
EUR 420

p38 MAPK Antibody

AF6456 200ul
EUR 420

p38 MAPK Antibody

AF6457 200ul
EUR 420

p38 Polyclonal Antibody

ES3111-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES3111-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES3112-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES3112-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4837-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4837-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

p38 Polyclonal Antibody

ES4838-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

p38 Polyclonal Antibody

ES4838-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Anti-p38 antibody

PAab06076 100 ug
EUR 426

anti-p38 MAPK

LF-PA0160 100 ul
EUR 400.8
Description: Rabbit polyclonal to p38 MAPK

anti- p38 antibody

FNab06076 100µg
EUR 606.3
Description: Antibody raised against p38

p38 Polyclonal Antibody

ES8347-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

p38 Polyclonal Antibody

ES8347-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against p38 from Human/Mouse/Rat/Chicken. This antibody is tested and validated for WB, ELISA, WB, ELISA

Anti-p38 antibody

STJ94876 200 µl
EUR 236.4
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94877 200 µl
EUR 236.4
Description: Rabbit polyclonal to p38.

Anti-p38 antibody

STJ94878 200 µl
EUR 236.4
Description: p38 is a protein encoded by the MAPK14 gene which is approximately 41,2 kDa. p38 is localised to the cytoplasm and nucleus. It is involved in activated TLR4 signalling, the IL-2 pathway, toll-like receptor signalling pathways, the VEGF signalling pathway and 4-1BB pathway. This protein falls under the MAP kinase family. It acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. p38 is expressed in the brain, heart, placenta, pancreas and skeletal muscle. Mutations in the MAPK14 gene may result in patellar tendinitis and lumbosacral lipoma. STJ94878 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p38 protein.

Anti-p38 antibody

STJ94879 200 µl
EUR 236.4
Description: Rabbit polyclonal to p38.

Anti-P38 antibody

STJ98898 200 µl
EUR 236.4
Description: Mouse monoclonal to P38.

Anti-P38 antibody

STJ98899 200 µl
EUR 236.4
Description: Mouse monoclonal to P38.

Anti-p38 antibody

STJ97615 200 µl
EUR 236.4
Description: Rabbit polyclonal to p38.

anti-Crk p38

YF-PA23509 50 ul
EUR 400.8
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11088 50 ul
EUR 435.6
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11089 50 ug
EUR 435.6
Description: Mouse polyclonal to Crk p38

anti-Crk p38

YF-PA11090 100 ug
EUR 483.6
Description: Rabbit polyclonal to Crk p38

anti-AIMP2/p38

YF-PA15507 50 ug
EUR 435.6
Description: Mouse polyclonal to AIMP2/p38

p38 alpha-MAPK14

RA15053 100 ug
EUR 631.2

Anti-p38 (3D5)

YF-MA12551 200 ul
EUR 435.6
Description: Mouse monoclonal to p38

Anti-p38 (1C9)

YF-MA12552 100 ug
EUR 435.6
Description: Mouse monoclonal to p38

p38 MAPK Antibody

R20266-0.1ML 100ul
EUR 409

Crk Antibody p38

R31526 100 ug
EUR 419

p38 Antibody (MAPK14)

F50496-0.08ML 0.08 ml
EUR 165

p38 Antibody (MAPK14)

F50496-0.4ML 0.4 ml
EUR 379

BP-1-102

HY-100493 100mg
EUR 1614

MM-102 (TFA)

HY-12220A 10mM/1mL
EUR 315.6


Cytomegalovirus (CMV) is a ubiquitous virus that infects people around the world. CMV is known to trigger thrombocytopenia, but the relationship is probably underdiagnosed since CMV infection in healthy adults usually either asymptomatic or cause mild symptoms. A systematic literature review conducted and produced 23 publications that reported in 25 patients. All hematology centers in Israel were searched for adult immunocompetent patients with CMV-related thrombocytopenia, and five new cases were identified. The average age of the combined 30 patients was 33 years (range 18-80), 73% were male, 77% presented with CMV-related symptoms, 48% had an enlarged spleen, 95% had atypical lymphocytes in the peripheral blood and 68% have increased transaminase levels.

The response rate for the first-line regimen containing steroids only 31%, while 11 patients were treated with anti-CMV agents have a response rate of 82%. In addition, four patients received receptor agonist thrombopoietin (TPO-RA) are three (75%) responded. Taken together, a typical feature of cases with thrombocytopenia must guard against CMV infection as the source.

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